Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2894730..2895439 Replicon chromosome
Accession NZ_CP041827
Organism Mycobacterium tuberculosis strain 3-0096P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPJ81_RS13420 Protein ID WP_003413164.1
Coordinates 2894730..2895143 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPJ81_RS13425 Protein ID WP_003413167.1
Coordinates 2895182..2895439 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ81_RS13390 2889783..2890988 - 1206 WP_003413027.1 chorismate synthase -
FPJ81_RS13395 2891096..2891410 + 315 WP_009937839.1 hypothetical protein -
FPJ81_RS13400 2891706..2892917 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPJ81_RS13405 2893044..2893703 + 660 WP_003900846.1 LppA family lipoprotein -
FPJ81_RS13410 2893700..2894362 + 663 WP_003903936.1 hypothetical protein -
FPJ81_RS13415 2894359..2894637 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FPJ81_RS13420 2894730..2895143 + 414 WP_003413164.1 PIN domain nuclease Toxin
FPJ81_RS13425 2895182..2895439 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ81_RS13430 2895436..2895813 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FPJ81_RS13435 2895829..2896203 - 375 WP_003413177.1 hypothetical protein -
FPJ81_RS13440 2896303..2896698 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPJ81_RS13445 2896695..2896940 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPJ81_RS13450 2897351..2897770 - 420 WP_003413190.1 A24 family peptidase -
FPJ81_RS13455 2897782..2898591 - 810 WP_003413193.1 shikimate dehydrogenase -
FPJ81_RS13460 2898588..2899841 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPJ81_RS13465 2899834..2900346 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T131652 WP_003413164.1 NZ_CP041827:2894730-2895143 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T131652 NZ_CP041827:2894730-2895143 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT131652 WP_003413167.1 NZ_CP041827:2895182-2895439 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT131652 NZ_CP041827:2895182-2895439 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References