Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 720217..720866 Replicon chromosome
Accession NZ_CP041827
Organism Mycobacterium tuberculosis strain 3-0096P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag FPJ81_RS03265 Protein ID WP_003403236.1
Coordinates 720471..720866 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag FPJ81_RS03260 Protein ID WP_003403235.1
Coordinates 720217..720471 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ81_RS03235 715342..715425 + 84 Protein_641 galactose-1-phosphate uridylyltransferase -
FPJ81_RS03240 715444..716526 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
FPJ81_RS03245 716523..717614 + 1092 WP_003900977.1 galactokinase -
FPJ81_RS03250 718009..719166 + 1158 WP_003903091.1 hypothetical protein -
FPJ81_RS03255 719177..720124 + 948 WP_003403232.1 DUF732 domain-containing protein -
FPJ81_RS03260 720217..720471 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
FPJ81_RS03265 720471..720866 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
FPJ81_RS03270 720960..721700 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
FPJ81_RS03275 721832..722092 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ81_RS03280 722089..722496 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
FPJ81_RS03285 722568..723719 - 1152 WP_003907440.1 FIST C-terminal domain-containing protein -
FPJ81_RS03290 723812..725539 - 1728 WP_019830517.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T131619 WP_003403236.1 NZ_CP041827:720471-720866 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T131619 NZ_CP041827:720471-720866 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT131619 WP_003403235.1 NZ_CP041827:720217-720471 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT131619 NZ_CP041827:720217-720471 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References