Detailed information of TA system TA131590

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2887809..2888449
• Replicon: chromosome
• Accession: NZ_CP041826
• Organism: Mycobacterium tuberculosis strain 3-0124P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: FPJ82_RS13360
• Protein ID: WP_003412970.1
• Coordinates: 2887809..2888228 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: FPJ82_RS13365
• Protein ID: WP_003412975.1
• Coordinates: 2888225..2888449 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ82_RS13330	2883394..2884116	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
FPJ82_RS13335	2884633..2884860	+	228	WP_003412960.1	type II toxin-antitoxin system VapB family antitoxin	-
FPJ82_RS13340	2884857..2885258	+	402	WP_003412963.1	PIN domain-containing protein	-
FPJ82_RS13345	2885293..2886213	-	921	WP_003412965.1	restriction endonuclease	-
FPJ82_RS13350	2886554..2886799	-	246	WP_071854223.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
FPJ82_RS13355	2886858..2887808	+	951	WP_003911916.1	Lsr2 family protein	-
FPJ82_RS13360	2887809..2888228	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ82_RS13365	2888225..2888449	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
FPJ82_RS13370	2888480..2891273	-	2794	Protein_2639	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
FPJ82_RS13375	2891345..2891746	-	402	WP_003412981.1	hypothetical protein	-
FPJ82_RS13380	2891746..2892216	-	471	WP_003412985.1	transcription antitermination factor NusB	-
FPJ82_RS13385	2892219..2892782	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T131590 WP_003412970.1 NZ_CP041826:c2888228-2887809 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T131590 NZ_CP041826:c2888228-2887809 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT131590 WP_003412975.1 NZ_CP041826:c2888449-2888225 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT131590 NZ_CP041826:c2888449-2888225 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09