Detailed information of TA system TA131538

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3027202..3027890
• Replicon: chromosome
• Accession: NZ_CP041825
• Organism: Mycobacterium tuberculosis strain 4-0010P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: FPJ83_RS14185
• Protein ID: WP_003406304.1
• Coordinates: 3027202..3027633 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: FPJ83_RS14190
• Protein ID: WP_003406302.1
• Coordinates: 3027630..3027890 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ83_RS14160	3022924..3023193	+	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FPJ83_RS14165	3023190..3023483	+	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
FPJ83_RS14170	3023540..3024370	+	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FPJ83_RS14175	3024451..3025311	-	861	WP_003900301.1	hypothetical protein	-
FPJ83_RS14180	3025491..3027179	+	1689	WP_003910308.1	PE family protein	-
FPJ83_RS14185	3027202..3027633	-	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ83_RS14190	3027630..3027890	-	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
FPJ83_RS14195	3027966..3028955	-	990	WP_003406301.1	malate dehydrogenase	-
FPJ83_RS14200	3029126..3030226	+	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
FPJ83_RS14205	3030303..3031484	-	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
FPJ83_RS14210	3031489..3032313	-	825	WP_003900298.1	trehalose ABC transporter permease SugB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T131538 WP_003406304.1 NZ_CP041825:c3027633-3027202 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T131538 NZ_CP041825:c3027633-3027202 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT131538 WP_003406302.1 NZ_CP041825:c3027890-3027630 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT131538 NZ_CP041825:c3027890-3027630 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6