Detailed information of TA system TA131531

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2454360..2454820
• Replicon: chromosome
• Accession: NZ_CP041825
• Organism: Mycobacterium tuberculosis strain 4-0010P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TKL9
• Locus tag: FPJ83_RS11655
• Protein ID: WP_003898996.1
• Coordinates: 2454360..2454608 (-)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FPJ83_RS11660
• Protein ID: WP_009938412.1
• Coordinates: 2454608..2454820 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ83_RS11635	2450534..2451145	+	612	WP_003898999.1	isopentenyl-diphosphate Delta-isomerase	-
FPJ83_RS11640	2451135..2451536	+	402	WP_003408538.1	hypothetical protein	-
FPJ83_RS11645	2451821..2453521	-	1701	WP_003898998.1	serine/threonine protein kinase PknE	-
FPJ83_RS11650	2453615..2454352	-	738	WP_003898997.1	hypothetical protein	-
FPJ83_RS11655	2454360..2454608	-	249	WP_003898996.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ83_RS11660	2454608..2454820	-	213	WP_009938412.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FPJ83_RS11665	2454888..2456570	+	1683	WP_003898994.1	SulP family inorganic anion transporter	-
FPJ83_RS11670	2456584..2456868	-	285	WP_003408522.1	DUF1876 domain-containing protein	-
FPJ83_RS11675	2457155..2458342	+	1188	WP_003898992.1	nitrate transporter NarK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin VapB-like (2-69)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 8884.14 Da
• Isoelectric Point: 4.1074

>T131531 WP_003898996.1 NZ_CP041825:c2454608-2454360 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Nucleotide

• Length: 249 bp

>T131531 NZ_CP041825:c2454608-2454360 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7665.84 Da
• Isoelectric Point: 7.9917

>AT131531 WP_009938412.1 NZ_CP041825:c2454820-2454608 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCEALPVLDTRAADTILGYDERGLPA

Nucleotide

• Length: 213 bp

>AT131531 NZ_CP041825:c2454820-2454608 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGAGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Structures

Toxin

• AlphaFold DB: G0TKL9