Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3706921..3707595 Replicon chromosome
Accession NZ_CP041823
Organism Mycobacterium tuberculosis strain 4-0019P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FPJ85_RS17380 Protein ID WP_003417282.1
Coordinates 3706921..3707349 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FPJ85_RS17385 Protein ID WP_003417286.1
Coordinates 3707353..3707595 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ85_RS17355 3702743..3703144 - 402 WP_003417264.1 cytidine deaminase -
FPJ85_RS17360 3703285..3703719 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
FPJ85_RS17365 3703716..3704150 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FPJ85_RS17370 3704279..3706051 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
FPJ85_RS17375 3706051..3706842 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FPJ85_RS17380 3706921..3707349 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ85_RS17385 3707353..3707595 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ85_RS17390 3707717..3708331 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
FPJ85_RS17395 3708328..3708993 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
FPJ85_RS17400 3708994..3709527 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
FPJ85_RS17405 3709524..3709898 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
FPJ85_RS17415 3711272..3711463 - 192 Protein_3439 RNA polymerase sigma factor SigJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-141)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T131424 WP_003417282.1 NZ_CP041823:c3707349-3706921 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T131424 NZ_CP041823:c3707349-3706921 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT131424 WP_003417286.1 NZ_CP041823:c3707595-3707353 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT131424 NZ_CP041823:c3707595-3707353 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0


Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References