Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/- |
Location | 2012352..2012881 | Replicon | chromosome |
Accession | NZ_CP041823 | ||
Organism | Mycobacterium tuberculosis strain 4-0019P6C4 |
Toxin (Protein)
Gene name | parE | Uniprot ID | G0TMR4 |
Locus tag | FPJ85_RS09565 | Protein ID | WP_003411124.1 |
Coordinates | 2012564..2012881 (+) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | P9WJ74 |
Locus tag | FPJ85_RS09560 | Protein ID | WP_003411127.1 |
Coordinates | 2012352..2012567 (+) | Length | 72 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FPJ85_RS09530 | 2007458..2008234 | + | 777 | WP_003411137.1 | YggS family pyridoxal phosphate-dependent enzyme | - |
FPJ85_RS09535 | 2008300..2008956 | + | 657 | WP_003411133.1 | cell division protein SepF | - |
FPJ85_RS09540 | 2009118..2009408 | + | 291 | WP_003900476.1 | YggT family protein | - |
FPJ85_RS09545 | 2009676..2010458 | + | 783 | WP_003411131.1 | cell wall synthesis protein Wag31 | - |
FPJ85_RS09550 | 2010553..2010909 | + | 357 | WP_003411130.1 | hypothetical protein | - |
FPJ85_RS09555 | 2011039..2012097 | - | 1059 | WP_003411129.1 | hypothetical protein | - |
FPJ85_RS09560 | 2012352..2012567 | + | 216 | WP_003411127.1 | antitoxin ParD2 | Antitoxin |
FPJ85_RS09565 | 2012564..2012881 | + | 318 | WP_003411124.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
FPJ85_RS09575 | 2013294..2014640 | + | 1347 | WP_003411121.1 | M20/M25/M40 family metallo-hydrolase | - |
FPJ85_RS09580 | 2014688..2015218 | + | 531 | WP_003411119.1 | YbhB/YbcL family Raf kinase inhibitor-like protein | - |
FPJ85_RS09585 | 2015223..2016296 | - | 1074 | WP_003411116.1 | quinone-dependent dihydroorotate dehydrogenase | - |
FPJ85_RS09590 | 2016332..2016613 | - | 282 | WP_003411112.1 | hypothetical protein | - |
FPJ85_RS09595 | 2016610..2017686 | - | 1077 | WP_003411110.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12312.88 Da Isoelectric Point: 6.4831
>T131399 WP_003411124.1 NZ_CP041823:2012564-2012881 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE
Download Length: 318 bp
>T131399 NZ_CP041823:2012564-2012881 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA
Antitoxin
Download Length: 72 a.a. Molecular weight: 7880.70 Da Isoelectric Point: 4.4055
>AT131399 WP_003411127.1 NZ_CP041823:2012352-2012567 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG
Download Length: 216 bp
>AT131399 NZ_CP041823:2012352-2012567 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TMR4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4FAJ4 |