Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1544849..1545558 Replicon chromosome
Accession NZ_CP041823
Organism Mycobacterium tuberculosis strain 4-0019P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPJ85_RS07390 Protein ID WP_003413164.1
Coordinates 1545145..1545558 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPJ85_RS07385 Protein ID WP_003413167.1
Coordinates 1544849..1545106 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ85_RS07345 1539942..1540454 + 513 WP_003413197.1 Holliday junction resolvase RuvX -
FPJ85_RS07350 1540447..1541700 + 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPJ85_RS07355 1541697..1542506 + 810 WP_003413193.1 shikimate dehydrogenase -
FPJ85_RS07360 1542518..1542937 + 420 WP_003413190.1 A24 family peptidase -
FPJ85_RS07365 1543348..1543593 + 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPJ85_RS07370 1543590..1543985 + 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPJ85_RS07375 1544085..1544459 + 375 WP_003413177.1 hypothetical protein -
FPJ85_RS07380 1544475..1544852 - 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FPJ85_RS07385 1544849..1545106 - 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ85_RS07390 1545145..1545558 - 414 WP_003413164.1 PIN domain nuclease Toxin
FPJ85_RS07395 1545651..1545929 - 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FPJ85_RS07400 1545926..1546588 - 663 WP_003900848.1 hypothetical protein -
FPJ85_RS07405 1546585..1547244 - 660 WP_003900846.1 LppA family lipoprotein -
FPJ85_RS07410 1547371..1548582 - 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPJ85_RS07415 1548878..1549192 - 315 WP_009937839.1 hypothetical protein -
FPJ85_RS07420 1549300..1550505 + 1206 WP_003413027.1 chorismate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T131396 WP_003413164.1 NZ_CP041823:c1545558-1545145 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T131396 NZ_CP041823:c1545558-1545145 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT131396 WP_003413167.1 NZ_CP041823:c1545106-1544849 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT131396 NZ_CP041823:c1545106-1544849 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References