Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1482929..1483643 Replicon chromosome
Accession NZ_CP041823
Organism Mycobacterium tuberculosis strain 4-0019P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag FPJ85_RS07105 Protein ID WP_003413460.1
Coordinates 1482929..1483369 (-) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag FPJ85_RS07110 Protein ID WP_003413456.1
Coordinates 1483356..1483643 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ85_RS07080 1478841..1479515 - 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -
FPJ85_RS07085 1479643..1480542 + 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
FPJ85_RS07090 1480571..1481416 + 846 WP_003413466.1 acyl-CoA thioesterase II -
FPJ85_RS07095 1481424..1482020 + 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
FPJ85_RS07100 1482153..1482908 + 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
FPJ85_RS07105 1482929..1483369 - 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ85_RS07110 1483356..1483643 - 288 WP_003413456.1 antitoxin VapB41 Antitoxin
FPJ85_RS07115 1483754..1485325 - 1572 WP_003899392.1 polyamine aminopropyltransferase -
FPJ85_RS07120 1485322..1485780 - 459 WP_003413451.1 DUF350 domain-containing protein -
FPJ85_RS07125 1485805..1486236 - 432 WP_003899390.1 DUF4247 domain-containing protein -
FPJ85_RS07130 1486233..1486727 - 495 WP_003413444.1 DUF2617 family protein -
FPJ85_RS07135 1486738..1487358 - 621 WP_003413441.1 DUF4178 domain-containing protein -
FPJ85_RS07140 1487575..1487979 - 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
FPJ85_RS07145 1487976..1488221 - 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T131393 WP_003413460.1 NZ_CP041823:c1483369-1482929 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T131393 NZ_CP041823:c1483369-1482929 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAAGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT131393 WP_003413456.1 NZ_CP041823:c1483643-1483356 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT131393 NZ_CP041823:c1483643-1483356 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References