Detailed information of TA system TA131363

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3706855..3707529
• Replicon: chromosome
• Accession: NZ_CP041822
• Organism: Mycobacterium tuberculosis strain 4-0024P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF52
• Locus tag: FPJ86_RS17380
• Protein ID: WP_003417282.1
• Coordinates: 3706855..3707283 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TI59
• Locus tag: FPJ86_RS17385
• Protein ID: WP_003417286.1
• Coordinates: 3707287..3707529 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ86_RS17355	3702677..3703078	-	402	WP_003417264.1	cytidine deaminase	-
FPJ86_RS17360	3703219..3703653	+	435	WP_003900017.1	succinate dehydrogenase, cytochrome b556 subunit	-
FPJ86_RS17365	3703650..3704084	+	435	WP_003417269.1	succinate dehydrogenase hydrophobic membrane anchor subunit	-
FPJ86_RS17370	3704213..3705985	+	1773	WP_003417273.1	succinate dehydrogenase flavoprotein subunit	-
FPJ86_RS17375	3705985..3706776	+	792	WP_003417279.1	succinate dehydrogenase iron-sulfur subunit	-
FPJ86_RS17380	3706855..3707283	-	429	WP_003417282.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ86_RS17385	3707287..3707529	-	243	WP_003417286.1	ribbon-helix-helix domain-containing protein	Antitoxin
FPJ86_RS17390	3707651..3708265	-	615	WP_003417288.1	class I SAM-dependent methyltransferase	-
FPJ86_RS17395	3708262..3708927	-	666	WP_003417290.1	molybdopterin converting factor subunit 1	-
FPJ86_RS17400	3708928..3709461	-	534	WP_003417293.1	cyclic pyranopterin monophosphate synthase MoaC	-
FPJ86_RS17405	3709458..3709832	-	375	WP_003417295.1	4a-hydroxytetrahydrobiopterin dehydratase	-
FPJ86_RS17415	3711206..3711397	-	192	Protein_3439	RNA polymerase sigma factor SigJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-141)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15834.16 Da
• Isoelectric Point: 8.5471

>T131363 WP_003417282.1 NZ_CP041822:c3707283-3706855 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Nucleotide

• Length: 429 bp

>T131363 NZ_CP041822:c3707283-3706855 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.86 Da
• Isoelectric Point: 5.1007

>AT131363 WP_003417286.1 NZ_CP041822:c3707529-3707287 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Nucleotide

• Length: 243 bp

>AT131363 NZ_CP041822:c3707529-3707287 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Structures

Toxin

• AlphaFold DB: A0A7U4FBL0

Antitoxin

• AlphaFold DB: G0TI59