Detailed information of TA system TA131356

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3027142..3027830
• Replicon: chromosome
• Accession: NZ_CP041822
• Organism: Mycobacterium tuberculosis strain 4-0024P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: FPJ86_RS14180
• Protein ID: WP_003406304.1
• Coordinates: 3027142..3027573 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: FPJ86_RS14185
• Protein ID: WP_003406302.1
• Coordinates: 3027570..3027830 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ86_RS14155	3022873..3023142	+	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FPJ86_RS14160	3023139..3023432	+	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
FPJ86_RS14165	3023489..3024319	+	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FPJ86_RS14170	3024400..3025260	-	861	WP_003900301.1	hypothetical protein	-
FPJ86_RS14175	3025440..3027119	+	1680	WP_031664113.1	PE family protein	-
FPJ86_RS14180	3027142..3027573	-	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ86_RS14185	3027570..3027830	-	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
FPJ86_RS14190	3027906..3028895	-	990	WP_003406301.1	malate dehydrogenase	-
FPJ86_RS14195	3029066..3030166	+	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
FPJ86_RS14200	3030243..3031424	-	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
FPJ86_RS14205	3031429..3032253	-	825	WP_003900298.1	trehalose ABC transporter permease SugB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T131356 WP_003406304.1 NZ_CP041822:c3027573-3027142 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T131356 NZ_CP041822:c3027573-3027142 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT131356 WP_003406302.1 NZ_CP041822:c3027830-3027570 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT131356 NZ_CP041822:c3027830-3027570 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6