Detailed information of TA system TA131349

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2454312..2454772
• Replicon: chromosome
• Accession: NZ_CP041822
• Organism: Mycobacterium tuberculosis strain 4-0024P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TKL9
• Locus tag: FPJ86_RS11660
• Protein ID: WP_003898996.1
• Coordinates: 2454312..2454560 (-)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FPJ86_RS11665
• Protein ID: WP_009938412.1
• Coordinates: 2454560..2454772 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ86_RS11640	2450486..2451097	+	612	WP_003898999.1	isopentenyl-diphosphate Delta-isomerase	-
FPJ86_RS11645	2451087..2451488	+	402	WP_003408538.1	hypothetical protein	-
FPJ86_RS11650	2451773..2453473	-	1701	WP_003898998.1	serine/threonine protein kinase PknE	-
FPJ86_RS11655	2453567..2454304	-	738	WP_003898997.1	hypothetical protein	-
FPJ86_RS11660	2454312..2454560	-	249	WP_003898996.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ86_RS11665	2454560..2454772	-	213	WP_009938412.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FPJ86_RS11670	2454840..2456522	+	1683	WP_003898994.1	SulP family inorganic anion transporter	-
FPJ86_RS11675	2456536..2456820	-	285	WP_003408522.1	DUF1876 domain-containing protein	-
FPJ86_RS11680	2457107..2458294	+	1188	WP_003898992.1	nitrate transporter NarK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin VapB-like (2-69)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 8884.14 Da
• Isoelectric Point: 4.1074

>T131349 WP_003898996.1 NZ_CP041822:c2454560-2454312 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Nucleotide

• Length: 249 bp

>T131349 NZ_CP041822:c2454560-2454312 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7665.84 Da
• Isoelectric Point: 7.9917

>AT131349 WP_009938412.1 NZ_CP041822:c2454772-2454560 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCEALPVLDTRAADTILGYDERGLPA

Nucleotide

• Length: 213 bp

>AT131349 NZ_CP041822:c2454772-2454560 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGAGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Structures

Toxin

• AlphaFold DB: G0TKL9