Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2218683..2219227 | Replicon | chromosome |
| Accession | NZ_CP041822 | ||
| Organism | Mycobacterium tuberculosis strain 4-0024P6C4 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | FPJ86_RS10555 | Protein ID | WP_003409896.1 |
| Coordinates | 2218931..2219227 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | FPJ86_RS10550 | Protein ID | WP_003409899.1 |
| Coordinates | 2218683..2218934 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FPJ86_RS10525 | 2214410..2215207 | - | 798 | WP_003899101.1 | ABC transporter permease | - |
| FPJ86_RS10530 | 2216106..2217326 | + | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| FPJ86_RS10535 | 2217359..2217631 | + | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FPJ86_RS10540 | 2217635..2218042 | + | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| FPJ86_RS10545 | 2218202..2218696 | - | 495 | WP_003899099.1 | hypothetical protein | - |
| FPJ86_RS10550 | 2218683..2218934 | + | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| FPJ86_RS10555 | 2218931..2219227 | + | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FPJ86_RS10560 | 2219276..2219890 | + | 615 | WP_003901296.1 | hypothetical protein | - |
| FPJ86_RS10565 | 2219779..2220324 | - | 546 | WP_003409891.1 | SecB-like chaperone | - |
| FPJ86_RS10570 | 2220321..2220770 | - | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| FPJ86_RS10575 | 2220812..2221189 | - | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| FPJ86_RS10580 | 2221164..2221685 | + | 522 | WP_003904745.1 | hypothetical protein | - |
| FPJ86_RS10585 | 2221659..2221970 | - | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| FPJ86_RS10590 | 2221967..2222182 | - | 216 | WP_003409878.1 | antitoxin | - |
| FPJ86_RS10595 | 2222422..2222718 | + | 297 | WP_003409877.1 | hypothetical protein | - |
| FPJ86_RS10600 | 2222719..2222910 | + | 192 | WP_003409876.1 | hypothetical protein | - |
| FPJ86_RS10605 | 2222931..2223833 | + | 903 | WP_003899097.1 | hypothetical protein | - |
| FPJ86_RS10610 | 2223844..2224194 | + | 351 | WP_003899096.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T131346 WP_003409896.1 NZ_CP041822:2218931-2219227 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T131346 NZ_CP041822:2218931-2219227 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT131346 WP_003409899.1 NZ_CP041822:2218683-2218934 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT131346 NZ_CP041822:2218683-2218934 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |