131342

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2164237..2164863 Replicon chromosome
Accession NZ_CP041822
Organism Mycobacterium tuberculosis strain 4-0024P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag FPJ86_RS10265 Protein ID WP_003410075.1
Coordinates 2164237..2164635 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag FPJ86_RS10270 Protein ID WP_003911750.1
Coordinates 2164636..2164863 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ86_RS10235 2159836..2161092 + 1257 WP_003410095.1 HNH endonuclease -
FPJ86_RS10240 2161220..2161810 - 591 WP_003899131.1 IS110 family transposase -
FPJ86_RS10245 2161764..2162411 - 648 WP_071854215.1 transposase -
FPJ86_RS10250 2162472..2162651 + 180 Protein_2018 hypothetical protein -
FPJ86_RS10255 2163088..2163522 - 435 WP_003914358.1 DUF1398 domain-containing protein -
FPJ86_RS10260 2163623..2164054 + 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
FPJ86_RS10265 2164237..2164635 - 399 WP_003410075.1 PIN domain nuclease Toxin
FPJ86_RS10270 2164636..2164863 - 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FPJ86_RS10275 2165122..2166291 + 1170 WP_003899126.1 ATP-binding protein -
FPJ86_RS10280 2166480..2166824 + 345 WP_003410065.1 ferredoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T131342 WP_003410075.1 NZ_CP041822:c2164635-2164237 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T131342 NZ_CP041822:c2164635-2164237 [Mycobacterium tuberculosis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT131342 WP_003911750.1 NZ_CP041822:c2164863-2164636 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT131342 NZ_CP041822:c2164863-2164636 [Mycobacterium tuberculosis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References