Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1604921..1605573 Replicon chromosome
Accession NZ_CP041822
Organism Mycobacterium tuberculosis strain 4-0024P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag FPJ86_RS07675 Protein ID WP_003412752.1
Coordinates 1604921..1605346 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag FPJ86_RS07680 Protein ID WP_003412749.1
Coordinates 1605352..1605573 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ86_RS07650 1599926..1600483 + 558 WP_003412768.1 MaoC family dehydratase -
FPJ86_RS07655 1600480..1601301 + 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
FPJ86_RS07660 1601560..1602663 + 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
FPJ86_RS07665 1602674..1603720 + 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
FPJ86_RS07670 1603717..1604898 + 1182 WP_003899351.1 2-oxo acid dehydrogenase subunit E2 -
FPJ86_RS07675 1604921..1605346 - 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ86_RS07680 1605352..1605573 - 222 WP_003412749.1 antitoxin Antitoxin
FPJ86_RS07690 1607140..1607736 - 597 Protein_1514 hypothetical protein -
FPJ86_RS07695 1607726..1608349 - 624 WP_003900858.1 TIGR00725 family protein -
FPJ86_RS07700 1608485..1608691 + 207 WP_003899347.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1605828..1606712 884


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T131337 WP_003412752.1 NZ_CP041822:c1605346-1604921 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T131337 NZ_CP041822:c1605346-1604921 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCTAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT131337 WP_003412749.1 NZ_CP041822:c1605573-1605352 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT131337 NZ_CP041822:c1605573-1605352 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References