Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 1544419..1545050 | Replicon | chromosome |
Accession | NZ_CP041822 | ||
Organism | Mycobacterium tuberculosis strain 4-0024P6C4 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQ28 |
Locus tag | FPJ86_RS07385 | Protein ID | WP_003413174.1 |
Coordinates | 1544419..1544796 (-) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P95006 |
Locus tag | FPJ86_RS07390 | Protein ID | WP_003413167.1 |
Coordinates | 1544793..1545050 (-) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FPJ86_RS07350 | 1539886..1540398 | + | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
FPJ86_RS07355 | 1540391..1541644 | + | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
FPJ86_RS07360 | 1541641..1542450 | + | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
FPJ86_RS07365 | 1542462..1542881 | + | 420 | WP_003413190.1 | A24 family peptidase | - |
FPJ86_RS07370 | 1543292..1543537 | + | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
FPJ86_RS07375 | 1543534..1543929 | + | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
FPJ86_RS07380 | 1544029..1544403 | + | 375 | WP_003413177.1 | hypothetical protein | - |
FPJ86_RS07385 | 1544419..1544796 | - | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
FPJ86_RS07390 | 1544793..1545050 | - | 258 | WP_003413167.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
FPJ86_RS07395 | 1545089..1545502 | - | 414 | WP_003413164.1 | PIN domain nuclease | - |
FPJ86_RS07400 | 1545595..1545873 | - | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
FPJ86_RS07405 | 1545870..1546532 | - | 663 | WP_003900848.1 | hypothetical protein | - |
FPJ86_RS07410 | 1546529..1547188 | - | 660 | WP_003900846.1 | LppA family lipoprotein | - |
FPJ86_RS07415 | 1547315..1548526 | - | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
FPJ86_RS07420 | 1548822..1549136 | - | 315 | WP_009937839.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13728.72 Da Isoelectric Point: 4.4687
>T131334 WP_003413174.1 NZ_CP041822:c1544796-1544419 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
Download Length: 378 bp
>T131334 NZ_CP041822:c1544796-1544419 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT131334 WP_003413167.1 NZ_CP041822:c1545050-1544793 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT131334 NZ_CP041822:c1545050-1544793 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQ28 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829C9W5 |