131332

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1482873..1483587 Replicon chromosome
Accession NZ_CP041822
Organism Mycobacterium tuberculosis strain 4-0024P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag FPJ86_RS07110 Protein ID WP_003413460.1
Coordinates 1482873..1483313 (-) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag FPJ86_RS07115 Protein ID WP_003413456.1
Coordinates 1483300..1483587 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ86_RS07085 1478785..1479459 - 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -
FPJ86_RS07090 1479587..1480486 + 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
FPJ86_RS07095 1480515..1481360 + 846 WP_003413466.1 acyl-CoA thioesterase II -
FPJ86_RS07100 1481368..1481964 + 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
FPJ86_RS07105 1482097..1482852 + 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
FPJ86_RS07110 1482873..1483313 - 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ86_RS07115 1483300..1483587 - 288 WP_003413456.1 antitoxin VapB41 Antitoxin
FPJ86_RS07120 1483698..1485269 - 1572 WP_003899392.1 polyamine aminopropyltransferase -
FPJ86_RS07125 1485266..1485724 - 459 WP_003413451.1 DUF350 domain-containing protein -
FPJ86_RS07130 1485749..1486180 - 432 WP_003899390.1 DUF4247 domain-containing protein -
FPJ86_RS07135 1486177..1486671 - 495 WP_003413444.1 DUF2617 family protein -
FPJ86_RS07140 1486682..1487302 - 621 WP_003413441.1 DUF4178 domain-containing protein -
FPJ86_RS07145 1487519..1487923 - 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
FPJ86_RS07150 1487920..1488165 - 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T131332 WP_003413460.1 NZ_CP041822:c1483313-1482873 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T131332 NZ_CP041822:c1483313-1482873 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT131332 WP_003413456.1 NZ_CP041822:c1483587-1483300 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT131332 NZ_CP041822:c1483587-1483300 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References