Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2855933..2856642 Replicon chromosome
Accession NZ_CP041821
Organism Mycobacterium tuberculosis strain 4-0062P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPJ88_RS13270 Protein ID WP_003413164.1
Coordinates 2855933..2856346 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPJ88_RS13275 Protein ID WP_003413167.1
Coordinates 2856385..2856642 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ88_RS13240 2850987..2852192 - 1206 WP_003413027.1 chorismate synthase -
FPJ88_RS13245 2852300..2852614 + 315 WP_009937839.1 hypothetical protein -
FPJ88_RS13250 2852910..2854121 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPJ88_RS13255 2854248..2854907 + 660 WP_003902296.1 hypothetical protein -
FPJ88_RS13260 2854904..2855566 + 663 WP_003905878.1 hypothetical protein -
FPJ88_RS13265 2855563..2855840 + 278 Protein_2618 type II toxin-antitoxin system VapB family antitoxin -
FPJ88_RS13270 2855933..2856346 + 414 WP_003413164.1 PIN domain nuclease Toxin
FPJ88_RS13275 2856385..2856642 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ88_RS13280 2856639..2857016 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FPJ88_RS13285 2857032..2857406 - 375 WP_003413177.1 hypothetical protein -
FPJ88_RS13290 2857506..2857901 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPJ88_RS13295 2857898..2858143 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPJ88_RS13300 2858554..2858973 - 420 WP_003413190.1 A24 family peptidase -
FPJ88_RS13305 2858985..2859794 - 810 WP_003413193.1 shikimate dehydrogenase -
FPJ88_RS13310 2859791..2861044 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPJ88_RS13315 2861037..2861549 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T131289 WP_003413164.1 NZ_CP041821:2855933-2856346 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T131289 NZ_CP041821:2855933-2856346 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT131289 WP_003413167.1 NZ_CP041821:2856385-2856642 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT131289 NZ_CP041821:2856385-2856642 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References