131235

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3119366..3119936 Replicon chromosome
Accession NZ_CP041820
Organism Mycobacterium tuberculosis strain 4-0073P6C4

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag FPJ89_RS14675 Protein ID WP_003414166.1
Coordinates 3119366..3119722 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag FPJ89_RS14680 Protein ID WP_003901465.1
Coordinates 3119706..3119936 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ89_RS14655 3114818..3116506 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
FPJ89_RS14660 3116510..3116836 - 327 WP_003414157.1 hypothetical protein -
FPJ89_RS14665 3117009..3117596 + 588 WP_023641719.1 DUF3558 family protein -
FPJ89_RS14670 3117615..3119264 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
FPJ89_RS14675 3119366..3119722 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
FPJ89_RS14680 3119706..3119936 - 231 WP_003901465.1 antitoxin MazE Antitoxin
FPJ89_RS14685 3119979..3121022 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
FPJ89_RS14690 3121213..3121488 + 276 WP_003911993.1 DUF1778 domain-containing protein -
FPJ89_RS14695 3121664..3121918 - 255 WP_003917684.1 hypothetical protein -
FPJ89_RS14700 3122066..3122470 + 405 WP_009938577.1 hypothetical protein -
FPJ89_RS14705 3122467..3122658 + 192 WP_003414184.1 hypothetical protein -
FPJ89_RS14710 3122722..3124011 + 1290 Protein_2903 transposase family protein -
FPJ89_RS14715 3124245..3124502 + 258 WP_003899489.1 hypothetical protein -
FPJ89_RS14720 3124607..3124918 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T131235 WP_003414166.1 NZ_CP041820:c3119722-3119366 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T131235 NZ_CP041820:c3119722-3119366 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT131235 WP_003901465.1 NZ_CP041820:c3119936-3119706 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT131235 NZ_CP041820:c3119936-3119706 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References