131228

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2878556..2879265 Replicon chromosome
Accession NZ_CP041820
Organism Mycobacterium tuberculosis strain 4-0073P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPJ89_RS13350 Protein ID WP_003413164.1
Coordinates 2878556..2878969 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPJ89_RS13355 Protein ID WP_003413167.1
Coordinates 2879008..2879265 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ89_RS13320 2873609..2874814 - 1206 WP_003413027.1 chorismate synthase -
FPJ89_RS13325 2874922..2875236 + 315 WP_009937839.1 hypothetical protein -
FPJ89_RS13330 2875532..2876743 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPJ89_RS13335 2876870..2877529 + 660 WP_003900846.1 LppA family lipoprotein -
FPJ89_RS13340 2877526..2878188 + 663 WP_003900848.1 hypothetical protein -
FPJ89_RS13345 2878185..2878463 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FPJ89_RS13350 2878556..2878969 + 414 WP_003413164.1 PIN domain nuclease Toxin
FPJ89_RS13355 2879008..2879265 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ89_RS13360 2879262..2879639 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FPJ89_RS13365 2879655..2880029 - 375 WP_003413177.1 hypothetical protein -
FPJ89_RS13370 2880129..2880524 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPJ89_RS13375 2880521..2880766 - 246 WP_192991471.1 type II toxin-antitoxin system antitoxin VapB20 -
FPJ89_RS13380 2881177..2881596 - 420 WP_003413190.1 A24 family peptidase -
FPJ89_RS13385 2881608..2882417 - 810 WP_003413193.1 shikimate dehydrogenase -
FPJ89_RS13390 2882414..2883667 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPJ89_RS13395 2883660..2884172 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T131228 WP_003413164.1 NZ_CP041820:2878556-2878969 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T131228 NZ_CP041820:2878556-2878969 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT131228 WP_003413167.1 NZ_CP041820:2879008-2879265 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT131228 NZ_CP041820:2879008-2879265 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References