Detailed information of TA system TA131180

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3692473..3693147
• Replicon: chromosome
• Accession: NZ_CP041819
• Organism: Mycobacterium tuberculosis strain 4-0077P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF52
• Locus tag: FPJ90_RS17335
• Protein ID: WP_003417282.1
• Coordinates: 3692473..3692901 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TI59
• Locus tag: FPJ90_RS17340
• Protein ID: WP_003417286.1
• Coordinates: 3692905..3693147 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ90_RS17310	3688295..3688696	-	402	WP_003417264.1	cytidine deaminase	-
FPJ90_RS17315	3688837..3689271	+	435	WP_003900017.1	succinate dehydrogenase, cytochrome b556 subunit	-
FPJ90_RS17320	3689268..3689702	+	435	WP_003902441.1	succinate dehydrogenase hydrophobic membrane anchor subunit	-
FPJ90_RS17325	3689831..3691603	+	1773	WP_003417273.1	succinate dehydrogenase flavoprotein subunit	-
FPJ90_RS17330	3691603..3692394	+	792	WP_003417279.1	succinate dehydrogenase iron-sulfur subunit	-
FPJ90_RS17335	3692473..3692901	-	429	WP_003417282.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ90_RS17340	3692905..3693147	-	243	WP_003417286.1	ribbon-helix-helix domain-containing protein	Antitoxin
FPJ90_RS17345	3693269..3693883	-	615	WP_003417288.1	class I SAM-dependent methyltransferase	-
FPJ90_RS17350	3693880..3694545	-	666	WP_003417290.1	molybdopterin converting factor subunit 1	-
FPJ90_RS17355	3694546..3695079	-	534	WP_003417293.1	cyclic pyranopterin monophosphate synthase MoaC	-
FPJ90_RS17360	3695076..3695450	-	375	WP_003417295.1	4a-hydroxytetrahydrobiopterin dehydratase	-
FPJ90_RS17365	3695547..3696611	-	1065	WP_003913037.1	GTP 3',8-cyclase MoaA	-
FPJ90_RS17370	3697256..3697474	+	219	WP_016810323.1	hypothetical protein	-
FPJ90_RS17375	3697415..3697797	-	383	Protein_3431	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-141)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15834.16 Da
• Isoelectric Point: 8.5471

>T131180 WP_003417282.1 NZ_CP041819:c3692901-3692473 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Nucleotide

• Length: 429 bp

>T131180 NZ_CP041819:c3692901-3692473 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.86 Da
• Isoelectric Point: 5.1007

>AT131180 WP_003417286.1 NZ_CP041819:c3693147-3692905 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Nucleotide

• Length: 243 bp

>AT131180 NZ_CP041819:c3693147-3692905 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Structures

Toxin

• AlphaFold DB: A0A7U4FBL0

Antitoxin

• AlphaFold DB: G0TI59