131176

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3118605..3119209 Replicon chromosome
Accession NZ_CP041819
Organism Mycobacterium tuberculosis strain 4-0077P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag FPJ90_RS14745 Protein ID WP_003414492.1
Coordinates 3118605..3118997 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag FPJ90_RS14750 Protein ID WP_003414495.1
Coordinates 3118994..3119209 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ90_RS14715 3113755..3114543 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
FPJ90_RS14720 3114877..3115422 - 546 WP_014584866.1 DUF1802 family protein -
FPJ90_RS14725 3115694..3116578 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
FPJ90_RS14730 3116581..3117468 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
FPJ90_RS14735 3117773..3118318 - 546 WP_003899500.1 DUF1802 family protein -
FPJ90_RS14740 3118315..3118584 - 270 WP_003414489.1 DUF2277 family protein -
FPJ90_RS14745 3118605..3118997 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ90_RS14750 3118994..3119209 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FPJ90_RS14755 3119256..3120005 + 750 WP_003902358.1 enoyl-CoA hydratase -
FPJ90_RS14760 3120084..3121166 - 1083 WP_003414499.1 ABC transporter ATP-binding protein -
FPJ90_RS14765 3121159..3122469 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -
FPJ90_RS14770 3122472..3123299 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
FPJ90_RS14775 3123296..3124207 - 912 WP_003902360.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T131176 WP_003414492.1 NZ_CP041819:c3118997-3118605 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T131176 NZ_CP041819:c3118997-3118605 [Mycobacterium tuberculosis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT131176 WP_003414495.1 NZ_CP041819:c3119209-3118994 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT131176 NZ_CP041819:c3119209-3118994 [Mycobacterium tuberculosis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References