Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3764234..3764763 Replicon chromosome
Accession NZ_CP041817
Organism Mycobacterium tuberculosis strain 4-0096P6C4

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag FPJ92_RS17525 Protein ID WP_003417760.1
Coordinates 3764506..3764763 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag FPJ92_RS17520 Protein ID WP_003417757.1
Coordinates 3764234..3764509 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ92_RS17500 3761032..3762469 - 1438 Protein_3456 FAD-binding oxidoreductase -
FPJ92_RS17505 3762572..3762961 + 390 WP_003417745.1 DUF732 domain-containing protein -
FPJ92_RS17510 3762975..3763268 - 294 WP_003417749.1 DUF3017 domain-containing protein -
FPJ92_RS17515 3763265..3764110 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
FPJ92_RS17520 3764234..3764509 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
FPJ92_RS17525 3764506..3764763 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
FPJ92_RS17530 3764805..3765995 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
FPJ92_RS17535 3766112..3766480 + 369 WP_003417765.1 FHA domain-containing protein -
FPJ92_RS17540 3766477..3767028 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
FPJ92_RS17545 3767035..3767616 - 582 WP_003417769.1 ATP/GTP-binding protein -
FPJ92_RS17550 3767597..3767965 - 369 WP_003417772.1 DUF742 domain-containing protein -
FPJ92_RS17555 3767943..3768335 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T131059 WP_003417760.1 NZ_CP041817:3764506-3764763 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T131059 NZ_CP041817:3764506-3764763 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT131059 WP_003417757.1 NZ_CP041817:3764234-3764509 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT131059 NZ_CP041817:3764234-3764509 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References