131046

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2862704..2863413 Replicon chromosome
Accession NZ_CP041817
Organism Mycobacterium tuberculosis strain 4-0096P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPJ92_RS13295 Protein ID WP_003413164.1
Coordinates 2862704..2863117 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPJ92_RS13300 Protein ID WP_003413167.1
Coordinates 2863156..2863413 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ92_RS13265 2857758..2858963 - 1206 WP_003413027.1 chorismate synthase -
FPJ92_RS13270 2859071..2859385 + 315 WP_009937839.1 hypothetical protein -
FPJ92_RS13275 2859681..2860892 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPJ92_RS13280 2861019..2861678 + 660 WP_003902296.1 hypothetical protein -
FPJ92_RS13285 2861675..2862337 + 663 WP_003905878.1 hypothetical protein -
FPJ92_RS13290 2862334..2862611 + 278 Protein_2623 type II toxin-antitoxin system VapB family antitoxin -
FPJ92_RS13295 2862704..2863117 + 414 WP_003413164.1 PIN domain nuclease Toxin
FPJ92_RS13300 2863156..2863413 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ92_RS13305 2863410..2863787 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FPJ92_RS13310 2863803..2864177 - 375 WP_003413177.1 hypothetical protein -
FPJ92_RS13315 2864277..2864672 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPJ92_RS13320 2864669..2864914 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPJ92_RS13325 2865325..2865744 - 420 WP_003413190.1 A24 family peptidase -
FPJ92_RS13330 2865756..2866565 - 810 WP_003413193.1 shikimate dehydrogenase -
FPJ92_RS13335 2866562..2867815 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPJ92_RS13340 2867808..2868320 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T131046 WP_003413164.1 NZ_CP041817:2862704-2863117 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T131046 NZ_CP041817:2862704-2863117 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT131046 WP_003413167.1 NZ_CP041817:2863156-2863413 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT131046 NZ_CP041817:2863156-2863413 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References