Detailed information of TA system TA131025

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1383426..1384114
• Replicon: chromosome
• Accession: NZ_CP041817
• Organism: Mycobacterium tuberculosis strain 4-0096P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: FPJ92_RS06485
• Protein ID: WP_003406304.1
• Coordinates: 1383683..1384114 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: FPJ92_RS06480
• Protein ID: WP_003406302.1
• Coordinates: 1383426..1383686 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ92_RS06460	1379003..1379827	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
FPJ92_RS06465	1379832..1381013	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
FPJ92_RS06470	1381090..1382190	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
FPJ92_RS06475	1382361..1383350	+	990	WP_003406301.1	malate dehydrogenase	-
FPJ92_RS06480	1383426..1383686	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
FPJ92_RS06485	1383683..1384114	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ92_RS06490	1384137..1385720	-	1584	WP_009940130.1	PE family protein	-
FPJ92_RS06495	1385900..1386760	+	861	WP_003900301.1	hypothetical protein	-
FPJ92_RS06500	1386841..1387671	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FPJ92_RS06505	1387728..1388021	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
FPJ92_RS06510	1388018..1388287	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T131025 WP_003406304.1 NZ_CP041817:1383683-1384114 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T131025 NZ_CP041817:1383683-1384114 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT131025 WP_003406302.1 NZ_CP041817:1383426-1383686 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT131025 NZ_CP041817:1383426-1383686 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6