Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1012330..1012949 Replicon chromosome
Accession NZ_CP041817
Organism Mycobacterium tuberculosis strain 4-0096P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag FPJ92_RS04760 Protein ID WP_003404726.1
Coordinates 1012515..1012949 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag FPJ92_RS04755 Protein ID WP_003898641.1
Coordinates 1012330..1012509 (+) Length 60 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ92_RS04740 1007803..1009383 + 1581 WP_003909313.1 serine hydrolase -
FPJ92_RS04745 1009380..1011773 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
FPJ92_RS04750 1012046..1012204 + 159 WP_003404720.1 hypothetical protein -
FPJ92_RS04755 1012330..1012509 + 180 WP_003898641.1 antitoxin Antitoxin
FPJ92_RS04760 1012515..1012949 + 435 WP_003404726.1 SRPBCC family protein Toxin
FPJ92_RS04765 1013047..1013820 + 774 WP_003404735.1 VOC family protein -
FPJ92_RS04770 1013885..1014334 + 450 WP_003404738.1 hypothetical protein -
FPJ92_RS04775 1014469..1014699 - 231 WP_003898642.1 hypothetical protein -
FPJ92_RS04780 1014866..1016374 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
FPJ92_RS04785 1016376..1017614 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-142)

Antitoxin

(4-50)


Sequences


Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T131020 WP_003404726.1 NZ_CP041817:1012515-1012949 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T131020 NZ_CP041817:1012515-1012949 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT131020 WP_003898641.1 NZ_CP041817:1012330-1012509 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT131020 NZ_CP041817:1012330-1012509 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References