Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2197577..2198280 Replicon chromosome
Accession NZ_CP041816
Organism Mycobacterium tuberculosis strain SEA00042P6C4

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag FPJ93_RS10090 Protein ID WP_003409778.1
Coordinates 2197577..2197906 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag FPJ93_RS10095 Protein ID WP_003409780.1
Coordinates 2197903..2198280 (-) Length 126 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ93_RS10070 2193960..2195030 + 1071 WP_003899091.1 epoxide hydrolase EphB -
FPJ93_RS10075 2195027..2195542 + 516 WP_003409718.1 flavin reductase family protein -
FPJ93_RS10080 2195539..2196600 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
FPJ93_RS10085 2196597..2197367 + 771 WP_003409775.1 SDR family oxidoreductase -
FPJ93_RS10090 2197577..2197906 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FPJ93_RS10095 2197903..2198280 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
FPJ93_RS10100 2198277..2198867 - 591 WP_003409784.1 SEC-C domain-containing protein -
FPJ93_RS10105 2198922..2200286 + 1365 WP_003903691.1 HNH endonuclease -
FPJ93_RS10110 2200441..2200893 - 453 WP_003899095.1 lipoprotein -
FPJ93_RS10115 2200957..2201358 + 402 WP_003409869.1 hypothetical protein -
FPJ93_RS10120 2201351..2201533 - 183 WP_003409870.1 hypothetical protein -
FPJ93_RS10125 2201647..2201997 - 351 WP_003899096.1 hypothetical protein -
FPJ93_RS10130 2202008..2202910 - 903 WP_003899097.1 hypothetical protein -
FPJ93_RS10135 2202931..2203122 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-103)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T130972 WP_003409778.1 NZ_CP041816:c2197906-2197577 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

>T130972 NZ_CP041816:c2197906-2197577 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT130972 WP_003409780.1 NZ_CP041816:c2198280-2197903 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp

>AT130972 NZ_CP041816:c2198280-2197903 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLK7


Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References