Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1389406..1390094 Replicon chromosome
Accession NZ_CP041816
Organism Mycobacterium tuberculosis strain SEA00042P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag FPJ93_RS06540 Protein ID WP_003406304.1
Coordinates 1389663..1390094 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag FPJ93_RS06535 Protein ID WP_003406302.1
Coordinates 1389406..1389666 (+) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ93_RS06515 1384983..1385807 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
FPJ93_RS06520 1385812..1386993 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
FPJ93_RS06525 1387070..1388170 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
FPJ93_RS06530 1388341..1389330 + 990 WP_003406301.1 malate dehydrogenase -
FPJ93_RS06535 1389406..1389666 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
FPJ93_RS06540 1389663..1390094 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ93_RS06545 1390117..1391805 - 1689 WP_003910308.1 PE family protein -
FPJ93_RS06550 1391985..1392845 + 861 WP_003900301.1 hypothetical protein -
FPJ93_RS06555 1392926..1393756 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
FPJ93_RS06560 1393813..1394106 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
FPJ93_RS06565 1394103..1394372 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-142)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T130964 WP_003406304.1 NZ_CP041816:1389663-1390094 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

>T130964 NZ_CP041816:1389663-1390094 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT130964 WP_003406302.1 NZ_CP041816:1389406-1389666 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp

>AT130964 NZ_CP041816:1389406-1389666 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0THR7


Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References