130950

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 707502..708145 Replicon chromosome
Accession NZ_CP041816
Organism Mycobacterium tuberculosis strain SEA00042P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag FPJ93_RS03195 Protein ID WP_003403187.1
Coordinates 707744..708145 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag FPJ93_RS03190 Protein ID WP_003403184.1
Coordinates 707502..707747 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ93_RS03155 702782..703312 - 531 WP_003917320.1 two component system sensor kinase HK2 -
FPJ93_RS03160 703296..704057 - 762 WP_003403148.1 two-component system response regulator TcrA -
FPJ93_RS03165 704114..704425 + 312 WP_003403164.1 hypothetical protein -
FPJ93_RS03170 704497..705447 + 951 WP_003900184.1 DUF1259 domain-containing protein -
FPJ93_RS03175 705688..706272 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
FPJ93_RS03180 706274..706984 + 711 Protein_630 transposase -
FPJ93_RS03185 706987..707457 + 471 WP_003898523.1 hypothetical protein -
FPJ93_RS03190 707502..707747 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FPJ93_RS03195 707744..708145 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ93_RS03200 708533..708700 - 168 WP_077385191.1 DUF3800 domain-containing protein -
FPJ93_RS03205 708733..708930 - 198 WP_003403191.1 hypothetical protein -
FPJ93_RS03210 709010..710167 - 1158 WP_003898524.1 hypothetical protein -
FPJ93_RS03215 710219..710440 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FPJ93_RS03220 710582..711187 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T130950 WP_003403187.1 NZ_CP041816:707744-708145 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T130950 NZ_CP041816:707744-708145 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT130950 WP_003403184.1 NZ_CP041816:707502-707747 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT130950 NZ_CP041816:707502-707747 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References