Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2891417..2892126 Replicon chromosome
Accession NZ_CP041813
Organism Mycobacterium tuberculosis strain SEA07010354P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPJ96_RS13440 Protein ID WP_003413164.1
Coordinates 2891417..2891830 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPJ96_RS13445 Protein ID WP_003413167.1
Coordinates 2891869..2892126 (+) Length 86 a.a.

Genomic Context

FPJ96_RS13415FPJ96_RS13420FPJ96_RS13425FPJ96_RS13430FPJ96_RS13435FPJ96_RS13440FPJ96_RS13445FPJ96_RS13450FPJ96_RS13410FPJ96_RS13455FPJ96_RS13460FPJ96_RS13465FPJ96_RS13470FPJ96_RS13475FPJ96_RS13480FPJ96_RS13485
Location: 2887784..2888098 (315 bp)
Type: Others
Protein ID: WP_009937839.1
Location: 2888394..2889605 (1212 bp)
Type: Others
Protein ID: WP_003900845.1
Location: 2889732..2890391 (660 bp)
Type: Others
Protein ID: WP_003900846.1
Location: 2890388..2891049 (662 bp)
Type: Others
Protein ID: Protein_2651
Location: 2891046..2891324 (279 bp)
Type: Others
Protein ID: WP_003901422.1
Location: 2891417..2891830 (414 bp)
Type: Toxin
Protein ID: WP_003413164.1
Location: 2891869..2892126 (258 bp)
Type: Antitoxin
Protein ID: WP_003413167.1
Location: 2892123..2892500 (378 bp)
Type: Others
Protein ID: WP_003413174.1
Location: 2886471..2887676 (1206 bp)
Type: Others
Protein ID: WP_003413027.1
Location: 2892516..2892890 (375 bp)
Type: Others
Protein ID: WP_003413177.1
Location: 2892990..2893385 (396 bp)
Type: Others
Protein ID: WP_003413180.1
Location: 2893382..2893627 (246 bp)
Type: Others
Protein ID: WP_003413183.1
Location: 2894038..2894457 (420 bp)
Type: Others
Protein ID: WP_003413190.1
Location: 2894469..2895278 (810 bp)
Type: Others
Protein ID: WP_003413193.1
Location: 2895275..2896528 (1254 bp)
Type: Others
Protein ID: WP_003413196.1
Location: 2896521..2897033 (513 bp)
Type: Others
Protein ID: WP_003413197.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPJ96_RS134102886471..2887676-1206WP_003413027.1chorismate synthase-
FPJ96_RS134152887784..2888098+315WP_009937839.1hypothetical protein-
FPJ96_RS134202888394..2889605+1212WP_003900845.1alpha/beta hydrolase family protein-
FPJ96_RS134252889732..2890391+660WP_003900846.1LppA family lipoprotein-
FPJ96_RS134302890388..2891049+662Protein_2651hypothetical protein-
FPJ96_RS134352891046..2891324+279WP_003901422.1type II toxin-antitoxin system VapB family antitoxin-
FPJ96_RS134402891417..2891830+414WP_003413164.1PIN domain nucleaseToxin
FPJ96_RS134452891869..2892126+258WP_003413167.1ribbon-helix-helix domain-containing proteinAntitoxin
FPJ96_RS134502892123..2892500+378WP_003413174.1type II toxin-antitoxin system VapC family toxin-
FPJ96_RS134552892516..2892890-375WP_003413177.1hypothetical protein-
FPJ96_RS134602892990..2893385-396WP_003413180.1type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20-
FPJ96_RS134652893382..2893627-246WP_003413183.1type II toxin-antitoxin system antitoxin VapB20-
FPJ96_RS134702894038..2894457-420WP_003413190.1A24 family peptidase-
FPJ96_RS134752894469..2895278-810WP_003413193.1shikimate dehydrogenase-
FPJ96_RS134802895275..2896528-1254WP_003413196.1endolytic transglycosylase MltG-
FPJ96_RS134852896521..2897033-513WP_003413197.1Holliday junction resolvase RuvX-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T130803 WP_003413164.1 NZ_CP041813:2891417-2891830 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T130803 NZ_CP041813:2891417-2891830 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT130803 WP_003413167.1 NZ_CP041813:2891869-2892126 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT130803 NZ_CP041813:2891869-2892126 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBG0TQ26

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A829C9W5

References