Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2249872..2250458 Replicon chromosome
Accession NZ_CP041813
Organism Mycobacterium tuberculosis strain SEA07010354P6C4

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag FPJ96_RS10465 Protein ID WP_003410010.1
Coordinates 2249872..2250216 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag FPJ96_RS10470 Protein ID WP_003410014.1
Coordinates 2250210..2250458 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ96_RS10430 2245351..2245581 + 231 WP_003409980.1 DUF167 domain-containing protein -
FPJ96_RS10435 2245666..2246577 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
FPJ96_RS10440 2246686..2247285 + 600 WP_003409989.1 L-lysine exporter -
FPJ96_RS10445 2248306..2248866 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
FPJ96_RS10450 2248863..2249204 - 342 WP_003410003.1 DUF2384 domain-containing protein -
FPJ96_RS10455 2249290..2249547 + 258 WP_003410006.1 hypothetical protein -
FPJ96_RS10460 2249448..2249783 - 336 WP_003410009.1 dehydrogenase -
FPJ96_RS10465 2249872..2250216 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
FPJ96_RS10470 2250210..2250458 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
FPJ96_RS10475 2250558..2252810 - 2253 WP_016719189.1 cation transporter ATPase CptG -
FPJ96_RS10480 2252807..2253079 - 273 WP_003410017.1 DUF1490 family protein -
FPJ96_RS10485 2253132..2253488 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
FPJ96_RS10490 2253645..2254412 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T130795 WP_003410010.1 NZ_CP041813:c2250216-2249872 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

>T130795 NZ_CP041813:c2250216-2249872 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT130795 WP_003410014.1 NZ_CP041813:c2250458-2250210 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp

>AT130795 NZ_CP041813:c2250458-2250210 [Mycobacterium tuberculosis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
PDB 7WJ0
PDB 7WNR
AlphaFold DB A0A7U4FAW9

References