Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2248306..2249204 Replicon chromosome
Accession NZ_CP041813
Organism Mycobacterium tuberculosis strain SEA07010354P6C4

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag FPJ96_RS10445 Protein ID WP_003410001.1
Coordinates 2248306..2248866 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag FPJ96_RS10450 Protein ID WP_003410003.1
Coordinates 2248863..2249204 (-) Length 114 a.a.

Genomic Context

FPJ96_RS10430FPJ96_RS10440FPJ96_RS10455FPJ96_RS10425FPJ96_RS10435FPJ96_RS10445FPJ96_RS10450FPJ96_RS10460FPJ96_RS10465FPJ96_RS10470FPJ96_RS10475FPJ96_RS10480FPJ96_RS10485
Location: 2245351..2245581 (231 bp)
Type: Others
Protein ID: WP_003409980.1
Location: 2246686..2247285 (600 bp)
Type: Others
Protein ID: WP_003409989.1
Location: 2249290..2249547 (258 bp)
Type: Others
Protein ID: WP_003410006.1
Location: 2244583..2245236 (654 bp)
Type: Others
Protein ID: WP_003409976.1
Location: 2245666..2246577 (912 bp)
Type: Others
Protein ID: WP_003409986.1
Location: 2248306..2248866 (561 bp)
Type: Toxin
Protein ID: WP_003410001.1
Location: 2248863..2249204 (342 bp)
Type: Antitoxin
Protein ID: WP_003410003.1
Location: 2249448..2249783 (336 bp)
Type: Others
Protein ID: WP_003410009.1
Location: 2249872..2250216 (345 bp)
Type: Others
Protein ID: WP_003410010.1
Location: 2250210..2250458 (249 bp)
Type: Others
Protein ID: WP_003410014.1
Location: 2250558..2252810 (2253 bp)
Type: Others
Protein ID: WP_016719189.1
Location: 2252807..2253079 (273 bp)
Type: Others
Protein ID: WP_003410017.1
Location: 2253132..2253488 (357 bp)
Type: Others
Protein ID: WP_003410018.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPJ96_RS104252244583..2245236-654WP_003409976.1cutinase Cfp21-
FPJ96_RS104302245351..2245581+231WP_003409980.1DUF167 domain-containing protein-
FPJ96_RS104352245666..2246577-912WP_003409986.1ArgP/LysG family DNA-binding transcriptional regulator-
FPJ96_RS104402246686..2247285+600WP_003409989.1L-lysine exporter-
FPJ96_RS104452248306..2248866-561WP_003410001.1RES family NAD+ phosphorylaseToxin
FPJ96_RS104502248863..2249204-342WP_003410003.1DUF2384 domain-containing proteinAntitoxin
FPJ96_RS104552249290..2249547+258WP_003410006.1hypothetical protein-
FPJ96_RS104602249448..2249783-336WP_003410009.1dehydrogenase-
FPJ96_RS104652249872..2250216-345WP_003410010.1type II toxin-antitoxin system toxin endoribonuclease MazF6-
FPJ96_RS104702250210..2250458-249WP_003410014.1ribbon-helix-helix protein, CopG family-
FPJ96_RS104752250558..2252810-2253WP_016719189.1cation transporter ATPase CptG-
FPJ96_RS104802252807..2253079-273WP_003410017.1DUF1490 family protein-
FPJ96_RS104852253132..2253488-357WP_003410018.1Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T130794 WP_003410001.1 NZ_CP041813:c2248866-2248306 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T130794 NZ_CP041813:c2248866-2248306 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT130794 WP_003410003.1 NZ_CP041813:c2249204-2248863 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT130794 NZ_CP041813:c2249204-2248863 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6FKG

Antitoxin

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Source
ID
Structure
PDB6FKG
AlphaFold DBA0A7U4FAE4

References