Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2215868..2216412 Replicon chromosome
Accession NZ_CP041813
Organism Mycobacterium tuberculosis strain SEA07010354P6C4

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag FPJ96_RS10260 Protein ID WP_003409896.1
Coordinates 2215868..2216164 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag FPJ96_RS10265 Protein ID WP_003409899.1
Coordinates 2216161..2216412 (-) Length 84 a.a.

Genomic Context

FPJ96_RS10225FPJ96_RS10230FPJ96_RS10240FPJ96_RS10245FPJ96_RS10250FPJ96_RS10270FPJ96_RS10290FPJ96_RS10205FPJ96_RS10210FPJ96_RS10215FPJ96_RS10220FPJ96_RS10235FPJ96_RS10255FPJ96_RS10260FPJ96_RS10265FPJ96_RS10275FPJ96_RS10280FPJ96_RS10285
Location: 2212913..2213128 (216 bp)
Type: Others
Protein ID: WP_003409878.1
Location: 2213125..2213436 (312 bp)
Type: Others
Protein ID: WP_003409881.1
Location: 2213906..2214283 (378 bp)
Type: Others
Protein ID: WP_010886136.1
Location: 2214325..2214774 (450 bp)
Type: Others
Protein ID: WP_003409886.1
Location: 2214771..2215316 (546 bp)
Type: Others
Protein ID: WP_003409891.1
Location: 2216399..2216893 (495 bp)
Type: Others
Protein ID: WP_003899099.1
Location: 2219888..2220685 (798 bp)
Type: Others
Protein ID: WP_003899101.1
Location: 2210901..2211251 (351 bp)
Type: Others
Protein ID: WP_003409871.1
Location: 2211262..2212164 (903 bp)
Type: Others
Protein ID: WP_003899097.1
Location: 2212185..2212376 (192 bp)
Type: Others
Protein ID: WP_003409876.1
Location: 2212377..2212673 (297 bp)
Type: Others
Protein ID: WP_003409877.1
Location: 2213410..2213931 (522 bp)
Type: Others
Protein ID: WP_003904745.1
Location: 2215205..2215819 (615 bp)
Type: Others
Protein ID: WP_003901296.1
Location: 2215868..2216164 (297 bp)
Type: Toxin
Protein ID: WP_003409896.1
Location: 2216161..2216412 (252 bp)
Type: Antitoxin
Protein ID: WP_003409899.1
Location: 2217053..2217460 (408 bp)
Type: Others
Protein ID: WP_003409913.1
Location: 2217464..2217736 (273 bp)
Type: Others
Protein ID: WP_031651155.1
Location: 2217769..2218989 (1221 bp)
Type: Others
Protein ID: WP_003409919.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPJ96_RS102052210901..2211251-351WP_003409871.1hypothetical protein-
FPJ96_RS102102211262..2212164-903WP_003899097.1hypothetical protein-
FPJ96_RS102152212185..2212376-192WP_003409876.1hypothetical protein-
FPJ96_RS102202212377..2212673-297WP_003409877.1hypothetical protein-
FPJ96_RS102252212913..2213128+216WP_003409878.1antitoxin-
FPJ96_RS102302213125..2213436+312WP_003409881.1type II toxin-antitoxin system VapC family toxin-
FPJ96_RS102352213410..2213931-522WP_003904745.1hypothetical protein-
FPJ96_RS102402213906..2214283+378WP_010886136.1type II toxin-antitoxin system toxin HigB-
FPJ96_RS102452214325..2214774+450WP_003409886.1type II toxin-antitoxin system antitoxin HigA-
FPJ96_RS102502214771..2215316+546WP_003409891.1SecB-like chaperone-
FPJ96_RS102552215205..2215819-615WP_003901296.1hypothetical protein-
FPJ96_RS102602215868..2216164-297WP_003409896.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FPJ96_RS102652216161..2216412-252WP_003409899.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
FPJ96_RS102702216399..2216893+495WP_003899099.1hypothetical protein-
FPJ96_RS102752217053..2217460-408WP_003409913.1type II toxin-antitoxin system VapC family toxin-
FPJ96_RS102802217464..2217736-273WP_031651155.1type II toxin-antitoxin system Phd/YefM family antitoxin-
FPJ96_RS102852217769..2218989-1221WP_003409919.1TetR family transcriptional regulator Mce3R-
FPJ96_RS102902219888..2220685+798WP_003899101.1ABC transporter permease-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T130792 WP_003409896.1 NZ_CP041813:c2216164-2215868 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T130792 NZ_CP041813:c2216164-2215868 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT130792 WP_003409899.1 NZ_CP041813:c2216412-2216161 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT130792 NZ_CP041813:c2216412-2216161 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBG0TLU9

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A7U4BUZ2

References