Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1246886..1247454 Replicon chromosome
Accession NZ_CP041813
Organism Mycobacterium tuberculosis strain SEA07010354P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TH08
Locus tag FPJ96_RS05885 Protein ID WP_003405865.1
Coordinates 1247080..1247454 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TH07
Locus tag FPJ96_RS05880 Protein ID WP_003405863.1
Coordinates 1246886..1247083 (+) Length 66 a.a.

Genomic Context

FPJ96_RS05865FPJ96_RS05875FPJ96_RS05880FPJ96_RS05885FPJ96_RS05890FPJ96_RS05895FPJ96_RS05905FPJ96_RS05915FPJ96_RS05860FPJ96_RS05870FPJ96_RS05900FPJ96_RS05910FPJ96_RS05920
Location: 1243655..1244662 (1008 bp)
Type: Others
Protein ID: WP_015629829.1
Location: 1245725..1246798 (1074 bp)
Type: Others
Protein ID: WP_003898732.1
Location: 1246886..1247083 (198 bp)
Type: Antitoxin
Protein ID: WP_003405863.1
Location: 1247080..1247454 (375 bp)
Type: Toxin
Protein ID: WP_003405865.1
Location: 1247657..1248355 (699 bp)
Type: Others
Protein ID: WP_016719357.1
Location: 1248473..1248658 (186 bp)
Type: Others
Protein ID: WP_003901093.1
Location: 1249103..1249426 (324 bp)
Type: Others
Protein ID: WP_003405871.1
Location: 1250173..1250382 (210 bp)
Type: Others
Protein ID: WP_003911400.1
Location: 1242927..1243565 (639 bp)
Type: Others
Protein ID: WP_003898730.1
Location: 1244679..1245662 (984 bp)
Type: Others
Protein ID: WP_003898731.1
Location: 1248585..1248860 (276 bp)
Type: Others
Protein ID: WP_003405867.1
Location: 1249441..1250151 (711 bp)
Type: Others
Protein ID: WP_003911399.1
Location: 1250334..1251041 (708 bp)
Type: Others
Protein ID: Protein_1166
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPJ96_RS058601242927..1243565-639WP_003898730.1lipid droplet-associated protein-
FPJ96_RS058651243655..1244662+1008WP_015629829.14-hydroxy-3-methylbut-2-enyl diphosphate reductase-
FPJ96_RS058701244679..1245662-984WP_003898731.1hypothetical protein-
FPJ96_RS058751245725..1246798+1074WP_003898732.1redox-regulated ATPase YchF-
FPJ96_RS058801246886..1247083+198WP_003405863.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
FPJ96_RS058851247080..1247454+375WP_003405865.1type II toxin-antitoxin system VapC family toxinToxin
FPJ96_RS058901247657..1248355+699WP_016719357.1hypothetical protein-
FPJ96_RS058951248473..1248658+186WP_003901093.1hypothetical protein-
FPJ96_RS059001248585..1248860-276WP_003405867.1hypothetical protein-
FPJ96_RS059051249103..1249426+324WP_003405871.1antibiotic biosynthesis monooxygenase-
FPJ96_RS059101249441..1250151-711WP_003911399.1hypothetical protein-
FPJ96_RS059151250173..1250382+210WP_003911400.1hypothetical protein-
FPJ96_RS059201250334..1251041-708Protein_1166adenylate/guanylate cyclase domain-containing protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13444.56 Da        Isoelectric Point: 5.1881

>T130781 WP_003405865.1 NZ_CP041813:1247080-1247454 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Download         Length: 375 bp

>T130781 NZ_CP041813:1247080-1247454 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6973.03 Da        Isoelectric Point: 11.7327

>AT130781 WP_003405863.1 NZ_CP041813:1246886-1247083 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Download         Length: 198 bp

>AT130781 NZ_CP041813:1246886-1247083 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBG0TH08

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBG0TH07

References