Detailed information of TA system TA130773

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 759490..760123
• Replicon: chromosome
• Accession: NZ_CP041813
• Organism: Mycobacterium tuberculosis strain SEA07010354P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FPJ96_RS03465
• Protein ID: WP_015629650.1
• Coordinates: 759490..759873 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ56
• Locus tag: FPJ96_RS03470
• Protein ID: WP_003403368.1
• Coordinates: 759968..760123 (-)
• Length: 52 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ96_RS03440	754781..755317	+	537	WP_003403341.1	50S ribosomal protein L10	-
FPJ96_RS03445	755354..755746	+	393	WP_003403353.1	50S ribosomal protein L7/L12	-
FPJ96_RS03450	755739..756434	-	696	WP_003403355.1	TetR/AcrR family transcriptional regulator	-
FPJ96_RS03455	756557..758011	+	1455	WP_049955505.1	carotenoid cleavage oxygenase	-
FPJ96_RS03460	758092..759102	+	1011	WP_003911248.1	ABC transporter ATP-binding protein	-
FPJ96_RS03465	759490..759873	-	384	WP_015629650.1	hypothetical protein	Toxin
FPJ96_RS03470	759968..760123	-	156	WP_003403368.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FPJ96_RS03475	760199..760915	-	717	WP_003403371.1	CPBP family intramembrane metalloprotease	-
FPJ96_RS03480	761191..761499	-	309	WP_003403376.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FPJ96_RS03485	761486..761731	-	246	WP_003403381.1	ribbon-helix-helix protein, CopG family	-
FPJ96_RS03490	761841..762278	-	438	WP_003403386.1	type II toxin-antitoxin system VapC family toxin	-
FPJ96_RS03495	762275..762529	-	255	WP_003911263.1	antitoxin VapB7	-
FPJ96_RS03500	762643..765006	+	2364	WP_003403397.1	arylsulfatase AtsD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-44)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 13886.68 Da
• Isoelectric Point: 6.0803

>T130773 WP_015629650.1 NZ_CP041813:c759873-759490 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRLIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Nucleotide

• Length: 384 bp

>T130773 NZ_CP041813:c759873-759490 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTTGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin

Protein

• Length: 52 a.a.
• Molecular weight: 5872.72 Da
• Isoelectric Point: 5.7734

>AT130773 WP_003403368.1 NZ_CP041813:c760123-759968 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Nucleotide

• Length: 156 bp

>AT130773 NZ_CP041813:c760123-759968 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4BSF8