Detailed information of TA system TA130761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 366486..367012
• Replicon: chromosome
• Accession: NZ_CP041813
• Organism: Mycobacterium tuberculosis strain SEA07010354P6C4

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: FPJ96_RS01590
• Protein ID: WP_015629470.1
• Coordinates: 366710..367012 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: P9WJ08
• Locus tag: FPJ96_RS01585
• Protein ID: WP_003401555.1
• Coordinates: 366486..366713 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ96_RS01570	362179..362982	-	804	WP_003401540.1	hypothetical protein	-
FPJ96_RS01575	362992..364389	-	1398	WP_003401544.1	sulfatase	-
FPJ96_RS01580	364568..366343	+	1776	WP_010886074.1	PE family protein	-
FPJ96_RS01585	366486..366713	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	Antitoxin
FPJ96_RS01590	366710..367012	+	303	WP_015629470.1	toxin-antitoxin system toxin	Toxin
FPJ96_RS01595	367060..367281	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	-
FPJ96_RS01600	367278..367703	+	426	WP_003401566.1	PIN domain nuclease	-
FPJ96_RS01605	367839..368471	+	633	WP_003401571.1	TetR/AcrR family transcriptional regulator	-
FPJ96_RS01610	368468..369376	+	909	WP_003900117.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10472.19 Da
• Isoelectric Point: 4.9609

>T130761 WP_015629470.1 NZ_CP041813:366710-367012 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRATDTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T130761 NZ_CP041813:366710-367012 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCACGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8130.21 Da
• Isoelectric Point: 7.0084

>AT130761 WP_003401555.1 NZ_CP041813:366486-366713 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT130761 NZ_CP041813:366486-366713 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCAGCCGGAAGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4F8T1