Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 717740..718389 Replicon chromosome
Accession NZ_CP041812
Organism Mycobacterium tuberculosis strain SEA07020250P6C4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FPJ97_RS03280 Protein ID WP_023641277.1
Coordinates 717994..718389 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag FPJ97_RS03275 Protein ID WP_003403235.1
Coordinates 717740..717994 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ97_RS03250 712866..713561 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
FPJ97_RS03255 713558..714049 + 492 WP_012054156.1 galactose-1-phosphate uridylyltransferase -
FPJ97_RS03260 714046..715137 + 1092 WP_003906403.1 galactokinase -
FPJ97_RS03265 715532..716596 + 1065 WP_003898532.1 hypothetical protein -
FPJ97_RS03270 716700..717647 + 948 WP_003403232.1 DUF732 domain-containing protein -
FPJ97_RS03275 717740..717994 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
FPJ97_RS03280 717994..718389 + 396 WP_023641277.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
FPJ97_RS03285 718483..719223 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
FPJ97_RS03290 719355..719615 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ97_RS03295 719612..720019 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
FPJ97_RS03300 720091..721242 - 1152 WP_003403248.1 FIST C-terminal domain-containing protein -
FPJ97_RS03305 721335..723062 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14264.07 Da        Isoelectric Point: 4.7475

>T130710 WP_023641277.1 NZ_CP041812:717994-718389 [Mycobacterium tuberculosis]
MVIDTSALVAMLTDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T130710 NZ_CP041812:717994-718389 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCACCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT130710 WP_003403235.1 NZ_CP041812:717740-717994 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT130710 NZ_CP041812:717740-717994 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References