Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 2872770..2873401 | Replicon | chromosome |
Accession | NZ_CP041811 | ||
Organism | Mycobacterium tuberculosis strain SEA08151P6C4 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQ28 |
Locus tag | FPJ98_RS13310 | Protein ID | WP_003413174.1 |
Coordinates | 2873024..2873401 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P95006 |
Locus tag | FPJ98_RS13305 | Protein ID | WP_003413167.1 |
Coordinates | 2872770..2873027 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FPJ98_RS13270 | 2868089..2868403 | + | 315 | WP_009937839.1 | hypothetical protein | - |
FPJ98_RS13275 | 2868699..2869849 | + | 1151 | Protein_2620 | alpha/beta hydrolase family protein | - |
FPJ98_RS13280 | 2869976..2870635 | + | 660 | WP_003900846.1 | LppA family lipoprotein | - |
FPJ98_RS13285 | 2870632..2871291 | + | 660 | WP_003900847.1 | hypothetical protein | - |
FPJ98_RS13290 | 2871288..2871950 | + | 663 | WP_003900848.1 | hypothetical protein | - |
FPJ98_RS13295 | 2871947..2872225 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
FPJ98_RS13300 | 2872318..2872731 | + | 414 | WP_003413164.1 | PIN domain nuclease | - |
FPJ98_RS13305 | 2872770..2873027 | + | 258 | WP_003413167.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
FPJ98_RS13310 | 2873024..2873401 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
FPJ98_RS13315 | 2873417..2873791 | - | 375 | WP_003413177.1 | hypothetical protein | - |
FPJ98_RS13320 | 2873891..2874286 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
FPJ98_RS13325 | 2874283..2874528 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
FPJ98_RS13330 | 2874939..2875358 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
FPJ98_RS13335 | 2875370..2876179 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
FPJ98_RS13340 | 2876176..2877429 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
FPJ98_RS13345 | 2877422..2877934 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13728.72 Da Isoelectric Point: 4.4687
>T130683 WP_003413174.1 NZ_CP041811:2873024-2873401 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
Download Length: 378 bp
>T130683 NZ_CP041811:2873024-2873401 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT130683 WP_003413167.1 NZ_CP041811:2872770-2873027 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT130683 NZ_CP041811:2872770-2873027 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQ28 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829C9W5 |