Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3700429..3701103 Replicon chromosome
Accession NZ_CP041810
Organism Mycobacterium tuberculosis strain SEA08162P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FPJ99_RS17360 Protein ID WP_003417282.1
Coordinates 3700429..3700857 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FPJ99_RS17365 Protein ID WP_003417286.1
Coordinates 3700861..3701103 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ99_RS17335 3696251..3696652 - 402 WP_003417264.1 cytidine deaminase -
FPJ99_RS17340 3696793..3697227 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
FPJ99_RS17345 3697224..3697658 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FPJ99_RS17350 3697787..3699559 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
FPJ99_RS17355 3699559..3700350 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FPJ99_RS17360 3700429..3700857 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ99_RS17365 3700861..3701103 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ99_RS17370 3701225..3701839 - 615 WP_193023958.1 class I SAM-dependent methyltransferase -
FPJ99_RS17375 3701836..3702048 - 213 Protein_3431 molybdenum cofactor biosynthesis protein MoaE -
FPJ99_RS17385 3703402..3703923 + 522 Protein_3433 NADP-dependent isocitrate dehydrogenase -
FPJ99_RS17390 3703990..3704634 - 645 WP_003905041.1 alpha/beta fold hydrolase -
FPJ99_RS17395 3704907..3705917 + 1011 WP_003417440.1 tryptophan--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T130634 WP_003417282.1 NZ_CP041810:c3700857-3700429 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T130634 NZ_CP041810:c3700857-3700429 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT130634 WP_003417286.1 NZ_CP041810:c3701103-3700861 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT130634 NZ_CP041810:c3701103-3700861 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References