Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2865595..2866304 Replicon chromosome
Accession NZ_CP041810
Organism Mycobacterium tuberculosis strain SEA08162P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPJ99_RS13315 Protein ID WP_003413164.1
Coordinates 2865595..2866008 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPJ99_RS13320 Protein ID WP_003413167.1
Coordinates 2866047..2866304 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ99_RS13285 2860648..2861853 - 1206 WP_003413027.1 chorismate synthase -
FPJ99_RS13290 2861961..2862275 + 315 WP_009937839.1 hypothetical protein -
FPJ99_RS13295 2862571..2863782 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPJ99_RS13300 2863909..2864568 + 660 WP_003900846.1 LppA family lipoprotein -
FPJ99_RS13305 2864565..2865227 + 663 WP_003900848.1 hypothetical protein -
FPJ99_RS13310 2865224..2865502 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FPJ99_RS13315 2865595..2866008 + 414 WP_003413164.1 PIN domain nuclease Toxin
FPJ99_RS13320 2866047..2866304 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ99_RS13325 2866301..2866678 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FPJ99_RS13330 2866694..2867068 - 375 WP_003413177.1 hypothetical protein -
FPJ99_RS13335 2867168..2867563 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPJ99_RS13340 2867560..2867805 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPJ99_RS13345 2868216..2868635 - 420 WP_003413190.1 A24 family peptidase -
FPJ99_RS13350 2868647..2869456 - 810 WP_003413193.1 shikimate dehydrogenase -
FPJ99_RS13355 2869453..2870706 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPJ99_RS13360 2870699..2871211 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T130621 WP_003413164.1 NZ_CP041810:2865595-2866008 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T130621 NZ_CP041810:2865595-2866008 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT130621 WP_003413167.1 NZ_CP041810:2866047-2866304 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT130621 NZ_CP041810:2866047-2866304 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References