Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2199561..2200105 Replicon chromosome
Accession NZ_CP041810
Organism Mycobacterium tuberculosis strain SEA08162P6C4

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag FPJ99_RS10180 Protein ID WP_003409896.1
Coordinates 2199561..2199857 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag FPJ99_RS10185 Protein ID WP_003409899.1
Coordinates 2199854..2200105 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ99_RS10125 2194594..2194944 - 351 WP_003899096.1 hypothetical protein -
FPJ99_RS10130 2194955..2195857 - 903 WP_193024035.1 hypothetical protein -
FPJ99_RS10135 2195878..2196069 - 192 WP_003409876.1 hypothetical protein -
FPJ99_RS10140 2196070..2196366 - 297 WP_003409877.1 hypothetical protein -
FPJ99_RS10145 2196606..2196821 + 216 WP_003409878.1 antitoxin -
FPJ99_RS10150 2196818..2197129 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPJ99_RS10155 2197103..2197624 - 522 WP_003904745.1 hypothetical protein -
FPJ99_RS10160 2197599..2197976 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
FPJ99_RS10165 2198018..2198467 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
FPJ99_RS10170 2198464..2199009 + 546 WP_003409891.1 SecB-like chaperone -
FPJ99_RS10175 2198898..2199512 - 615 WP_003901296.1 hypothetical protein -
FPJ99_RS10180 2199561..2199857 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPJ99_RS10185 2199854..2200105 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FPJ99_RS10190 2200092..2200586 + 495 WP_003899099.1 hypothetical protein -
FPJ99_RS10195 2200746..2201153 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPJ99_RS10200 2201157..2201429 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ99_RS10205 2201462..2202682 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
FPJ99_RS10210 2203581..2204378 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-93)

Antitoxin

(2-80)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T130610 WP_003409896.1 NZ_CP041810:c2199857-2199561 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T130610 NZ_CP041810:c2199857-2199561 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT130610 WP_003409899.1 NZ_CP041810:c2200105-2199854 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT130610 NZ_CP041810:c2200105-2199854 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLU9


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References