Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 1243261..1243829 | Replicon | chromosome |
Accession | NZ_CP041810 | ||
Organism | Mycobacterium tuberculosis strain SEA08162P6C4 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TH08 |
Locus tag | FPJ99_RS05885 | Protein ID | WP_003405865.1 |
Coordinates | 1243455..1243829 (+) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TH07 |
Locus tag | FPJ99_RS05880 | Protein ID | WP_003405863.1 |
Coordinates | 1243261..1243458 (+) | Length | 66 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FPJ99_RS05860 | 1239302..1239940 | - | 639 | WP_003898730.1 | lipid droplet-associated protein | - |
FPJ99_RS05865 | 1240030..1241037 | + | 1008 | WP_003405853.1 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | - |
FPJ99_RS05870 | 1241054..1242037 | - | 984 | WP_003898731.1 | hypothetical protein | - |
FPJ99_RS05875 | 1242100..1243173 | + | 1074 | WP_003898732.1 | redox-regulated ATPase YchF | - |
FPJ99_RS05880 | 1243261..1243458 | + | 198 | WP_003405863.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
FPJ99_RS05885 | 1243455..1243829 | + | 375 | WP_003405865.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
FPJ99_RS05890 | 1244032..1244730 | + | 699 | WP_003898733.1 | hypothetical protein | - |
FPJ99_RS05895 | 1244848..1245033 | + | 186 | WP_003901093.1 | hypothetical protein | - |
FPJ99_RS05900 | 1244960..1245235 | - | 276 | WP_003405867.1 | hypothetical protein | - |
FPJ99_RS05905 | 1245478..1245801 | + | 324 | WP_003405871.1 | antibiotic biosynthesis monooxygenase | - |
FPJ99_RS05910 | 1245816..1246526 | - | 711 | WP_003911399.1 | hypothetical protein | - |
FPJ99_RS05915 | 1246548..1246757 | + | 210 | WP_003911400.1 | hypothetical protein | - |
FPJ99_RS05920 | 1246709..1247416 | - | 708 | Protein_1166 | adenylate/guanylate cyclase domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13444.56 Da Isoelectric Point: 5.1881
>T130599 WP_003405865.1 NZ_CP041810:1243455-1243829 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS
Download Length: 375 bp
>T130599 NZ_CP041810:1243455-1243829 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA
Antitoxin
Download Length: 66 a.a. Molecular weight: 6973.03 Da Isoelectric Point: 11.7327
>AT130599 WP_003405863.1 NZ_CP041810:1243261-1243458 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR
Download Length: 198 bp
>AT130599 NZ_CP041810:1243261-1243458 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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