Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3688297..3688971 Replicon chromosome
Accession NZ_CP041809
Organism Mycobacterium tuberculosis strain SEA09020048P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FPK00_RS17285 Protein ID WP_003417282.1
Coordinates 3688297..3688725 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FPK00_RS17290 Protein ID WP_003417286.1
Coordinates 3688729..3688971 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK00_RS17260 3684119..3684520 - 402 WP_003417264.1 cytidine deaminase -
FPK00_RS17265 3684661..3685095 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
FPK00_RS17270 3685092..3685526 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FPK00_RS17275 3685655..3687427 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
FPK00_RS17280 3687427..3688218 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FPK00_RS17285 3688297..3688725 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK00_RS17290 3688729..3688971 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
FPK00_RS17295 3689093..3689707 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
FPK00_RS17300 3689704..3690369 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
FPK00_RS17305 3690370..3690903 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
FPK00_RS17310 3690900..3691274 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
FPK00_RS17315 3691371..3692435 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-141)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T130573 WP_003417282.1 NZ_CP041809:c3688725-3688297 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T130573 NZ_CP041809:c3688725-3688297 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT130573 WP_003417286.1 NZ_CP041809:c3688971-3688729 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT130573 NZ_CP041809:c3688971-3688729 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0


Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References