Detailed information of TA system TA130539

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1387556..1388244
• Replicon: chromosome
• Accession: NZ_CP041809
• Organism: Mycobacterium tuberculosis strain SEA09020048P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: FPK00_RS06510
• Protein ID: WP_003406304.1
• Coordinates: 1387813..1388244 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: FPK00_RS06505
• Protein ID: WP_003406302.1
• Coordinates: 1387556..1387816 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK00_RS06485	1383133..1383957	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
FPK00_RS06490	1383962..1385143	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
FPK00_RS06495	1385220..1386320	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
FPK00_RS06500	1386491..1387480	+	990	WP_003406301.1	malate dehydrogenase	-
FPK00_RS06505	1387556..1387816	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
FPK00_RS06510	1387813..1388244	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPK00_RS06515	1388267..1389955	-	1689	WP_003910308.1	PE family protein	-
FPK00_RS06520	1390135..1390995	+	861	WP_023637383.1	hypothetical protein	-
FPK00_RS06525	1391076..1391906	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FPK00_RS06530	1391963..1392256	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
FPK00_RS06535	1392253..1392522	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T130539 WP_003406304.1 NZ_CP041809:1387813-1388244 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T130539 NZ_CP041809:1387813-1388244 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT130539 WP_003406302.1 NZ_CP041809:1387556-1387816 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT130539 NZ_CP041809:1387556-1387816 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6