Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3691380..3692054 Replicon chromosome
Accession NZ_CP041808
Organism Mycobacterium tuberculosis strain SEA09167P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FPK01_RS17330 Protein ID WP_003417282.1
Coordinates 3691380..3691808 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FPK01_RS17335 Protein ID WP_003417286.1
Coordinates 3691812..3692054 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK01_RS17305 3687202..3687603 - 402 WP_003417264.1 cytidine deaminase -
FPK01_RS17310 3687744..3688178 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
FPK01_RS17315 3688175..3688609 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FPK01_RS17320 3688738..3690510 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
FPK01_RS17325 3690510..3691301 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FPK01_RS17330 3691380..3691808 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK01_RS17335 3691812..3692054 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
FPK01_RS17340 3692176..3692790 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
FPK01_RS17345 3692787..3693452 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
FPK01_RS17350 3693453..3693986 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
FPK01_RS17355 3693983..3694357 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
FPK01_RS17365 3695812..3696876 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T130512 WP_003417282.1 NZ_CP041808:c3691808-3691380 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T130512 NZ_CP041808:c3691808-3691380 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT130512 WP_003417286.1 NZ_CP041808:c3692054-3691812 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT130512 NZ_CP041808:c3692054-3691812 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References