Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2191685..2192229 Replicon chromosome
Accession NZ_CP041808
Organism Mycobacterium tuberculosis strain SEA09167P6C4

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag FPK01_RS10165 Protein ID WP_003409896.1
Coordinates 2191685..2191981 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag FPK01_RS10170 Protein ID WP_003409899.1
Coordinates 2191978..2192229 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK01_RS10110 2186718..2187068 - 351 WP_003899096.1 hypothetical protein -
FPK01_RS10115 2187079..2187981 - 903 WP_003899097.1 hypothetical protein -
FPK01_RS10120 2188002..2188193 - 192 WP_003409876.1 hypothetical protein -
FPK01_RS10125 2188194..2188490 - 297 WP_003409877.1 hypothetical protein -
FPK01_RS10130 2188730..2188945 + 216 WP_003409878.1 antitoxin -
FPK01_RS10135 2188942..2189253 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPK01_RS10140 2189227..2189748 - 522 WP_193019719.1 hypothetical protein -
FPK01_RS10145 2189723..2190100 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
FPK01_RS10150 2190142..2190591 + 450 WP_193019720.1 type II toxin-antitoxin system antitoxin HigA -
FPK01_RS10155 2190588..2191133 + 546 WP_003409891.1 SecB-like chaperone -
FPK01_RS10160 2191022..2191636 - 615 WP_003901296.1 hypothetical protein -
FPK01_RS10165 2191685..2191981 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPK01_RS10170 2191978..2192229 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FPK01_RS10175 2192216..2192710 + 495 WP_003899099.1 hypothetical protein -
FPK01_RS10180 2192870..2193277 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPK01_RS10185 2193281..2193553 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPK01_RS10190 2193586..2194806 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
FPK01_RS10195 2195705..2196502 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-93)

Antitoxin

(2-80)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T130488 WP_003409896.1 NZ_CP041808:c2191981-2191685 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T130488 NZ_CP041808:c2191981-2191685 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT130488 WP_003409899.1 NZ_CP041808:c2192229-2191978 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT130488 NZ_CP041808:c2192229-2191978 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLU9


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References