Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3691669..3692343 Replicon chromosome
Accession NZ_CP041807
Organism Mycobacterium tuberculosis strain SEA11020038P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FPK02_RS17290 Protein ID WP_003417282.1
Coordinates 3691669..3692097 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FPK02_RS17295 Protein ID WP_003417286.1
Coordinates 3692101..3692343 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK02_RS17265 3687491..3687892 - 402 WP_003417264.1 cytidine deaminase -
FPK02_RS17270 3688033..3688467 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
FPK02_RS17275 3688464..3688898 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FPK02_RS17280 3689027..3690799 + 1773 WP_031656052.1 succinate dehydrogenase flavoprotein subunit -
FPK02_RS17285 3690799..3691590 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FPK02_RS17290 3691669..3692097 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK02_RS17295 3692101..3692343 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
FPK02_RS17300 3692465..3693079 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
FPK02_RS17305 3693076..3693741 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
FPK02_RS17310 3693742..3694275 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
FPK02_RS17315 3694272..3694646 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
FPK02_RS17320 3694743..3695807 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T130451 WP_003417282.1 NZ_CP041807:c3692097-3691669 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T130451 NZ_CP041807:c3692097-3691669 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT130451 WP_003417286.1 NZ_CP041807:c3692343-3692101 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT130451 NZ_CP041807:c3692343-3692101 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References