Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2869209..2869918 Replicon chromosome
Accession NZ_CP041807
Organism Mycobacterium tuberculosis strain SEA11020038P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPK02_RS13330 Protein ID WP_003413164.1
Coordinates 2869209..2869622 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPK02_RS13335 Protein ID WP_003413167.1
Coordinates 2869661..2869918 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK02_RS13300 2864262..2865467 - 1206 WP_031654763.1 chorismate synthase -
FPK02_RS13305 2865575..2865889 + 315 WP_009937839.1 hypothetical protein -
FPK02_RS13310 2866185..2867396 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPK02_RS13315 2867523..2868182 + 660 WP_003900846.1 LppA family lipoprotein -
FPK02_RS13320 2868179..2868841 + 663 WP_003900848.1 hypothetical protein -
FPK02_RS13325 2868838..2869116 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FPK02_RS13330 2869209..2869622 + 414 WP_003413164.1 PIN domain nuclease Toxin
FPK02_RS13335 2869661..2869918 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPK02_RS13340 2869915..2870292 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FPK02_RS13345 2870308..2870682 - 375 WP_003413177.1 hypothetical protein -
FPK02_RS13350 2870782..2871177 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPK02_RS13355 2871174..2871419 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPK02_RS13360 2871830..2872249 - 420 WP_003413190.1 A24 family peptidase -
FPK02_RS13365 2872261..2873070 - 810 WP_003413193.1 shikimate dehydrogenase -
FPK02_RS13370 2873067..2874323 - 1257 WP_014585306.1 endolytic transglycosylase MltG -
FPK02_RS13375 2874316..2874828 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T130439 WP_003413164.1 NZ_CP041807:2869209-2869622 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T130439 NZ_CP041807:2869209-2869622 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT130439 WP_003413167.1 NZ_CP041807:2869661-2869918 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT130439 NZ_CP041807:2869661-2869918 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References