Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2208341..2208885 Replicon chromosome
Accession NZ_CP041807
Organism Mycobacterium tuberculosis strain SEA11020038P6C4

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag FPK02_RS10215 Protein ID WP_003409896.1
Coordinates 2208341..2208637 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag FPK02_RS10220 Protein ID WP_003409899.1
Coordinates 2208634..2208885 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK02_RS10160 2203374..2203724 - 351 WP_003899096.1 hypothetical protein -
FPK02_RS10165 2203735..2204637 - 903 WP_003899097.1 hypothetical protein -
FPK02_RS10170 2204658..2204849 - 192 WP_003409876.1 hypothetical protein -
FPK02_RS10175 2204850..2205146 - 297 WP_003409877.1 hypothetical protein -
FPK02_RS10180 2205386..2205601 + 216 WP_003409878.1 antitoxin -
FPK02_RS10185 2205598..2205909 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPK02_RS10190 2205883..2206404 - 522 WP_003904745.1 hypothetical protein -
FPK02_RS10195 2206379..2206756 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
FPK02_RS10200 2206798..2207247 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
FPK02_RS10205 2207244..2207789 + 546 WP_003409891.1 SecB-like chaperone -
FPK02_RS10210 2207678..2208292 - 615 WP_003901296.1 hypothetical protein -
FPK02_RS10215 2208341..2208637 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPK02_RS10220 2208634..2208885 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FPK02_RS10225 2208872..2209366 + 495 WP_003899099.1 hypothetical protein -
FPK02_RS10230 2209526..2209933 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPK02_RS10235 2209937..2210209 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPK02_RS10240 2210242..2211462 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
FPK02_RS10245 2212361..2213158 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-93)

Antitoxin

(2-80)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T130428 WP_003409896.1 NZ_CP041807:c2208637-2208341 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T130428 NZ_CP041807:c2208637-2208341 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT130428 WP_003409899.1 NZ_CP041807:c2208885-2208634 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT130428 NZ_CP041807:c2208885-2208634 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLU9


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References