Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1972466..1972926 Replicon chromosome
Accession NZ_CP041807
Organism Mycobacterium tuberculosis strain SEA11020038P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag FPK02_RS09110 Protein ID WP_003898996.1
Coordinates 1972678..1972926 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag FPK02_RS09105 Protein ID WP_003408528.1
Coordinates 1972466..1972678 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK02_RS09090 1968945..1970132 - 1188 WP_003898992.1 nitrate transporter NarK -
FPK02_RS09095 1970419..1970703 + 285 WP_003408522.1 DUF1876 domain-containing protein -
FPK02_RS09100 1970717..1972398 - 1682 Protein_1795 SulP family inorganic anion transporter -
FPK02_RS09105 1972466..1972678 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FPK02_RS09110 1972678..1972926 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
FPK02_RS09115 1972934..1973671 + 738 WP_003898997.1 hypothetical protein -
FPK02_RS09120 1973765..1975465 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
FPK02_RS09125 1975750..1976151 - 402 WP_003408538.1 hypothetical protein -
FPK02_RS09130 1976141..1976752 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T130425 WP_003898996.1 NZ_CP041807:1972678-1972926 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T130425 NZ_CP041807:1972678-1972926 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT130425 WP_003408528.1 NZ_CP041807:1972466-1972678 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT130425 NZ_CP041807:1972466-1972678 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References